Orion Biomedica

Microbiome Therapy

Microbiome therapy is a central component of modern, evidence-based medicine and is used to support both physical and mental health. The gut microbiome—comprising billions of microorganisms—has a significant influence on digestion, immune function, energy metabolism, and neurochemistry. Imbalances in the gut flora can contribute to a wide range of health issues, including irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), autoimmune conditions, allergies, mental health disorders, and metabolic disturbances.

📌 Interested in how we map the microbiome? Read about microbiome analysis

How Microbiome Therapy Works

Microbiome therapy involves the targeted use of prebiotics, probiotics, and personalized strategies based on an individual’s microbiome profile. Treatment is designed to:

  • Restore a healthy gut flora
  • Reduce inflammation
  • Strengthen the intestinal barrier and prevent “leaky gut”
  • Optimize neurotransmitter balance (e.g., serotonin, GABA)

Advanced stool analysis is used to identify imbalances within the gut microbiome, forming the foundation for a tailored treatment plan.

📌 Read how microbiome analysis provides the basis for personalized therapy

Individually Tailored Probiotics

A key element of microbiome therapy is the use of personalized probiotic formulations selected according to the patient’s specific needs. These are chosen based on:

  • The current status of the microbiome
  • Presence of specific imbalances such as low butyrate levels, mucin deficiency, or overgrowth of pathogenic strains
  • The patient’s clinical presentation (e.g., IBS, food intolerances, inflammation, or neurological issues)

Documented probiotic strains used in therapy include:

  • Lactobacillus rhamnosus – Supports mucosal integrity and reduces inflammation
  • Bifidobacterium longum – Modulates the immune system and supports mental health
  • Akkermansia muciniphila – Enhances the gut barrier and improves metabolic function

Indications for Microbiome Therapy

Microbiome therapy may be relevant in a wide range of clinical conditions, including:

  • Digestive issues – IBS, bloating, diarrhea, constipation, and food intolerances
  • Mental health disorders – Depression, anxiety, autism, and ADHD, linked to the gut–brain axis
  • Autoimmune conditions – Hashimoto’s thyroiditis, rheumatoid arthritis, celiac disease
  • Chronic inflammatory diseases – Ulcerative colitis, Crohn’s disease, metabolic syndrome
  • Allergies and intolerances – Food allergies, histamine intolerance
  • Skin conditions – Acne, eczema, psoriasis
  • Metabolic diseases – Obesity, diabetes, insulin resistance

Personalized Microbiome Therapy

Advanced stool testing is used to identify specific imbalances in gut flora. A customized plan is then developed, which may include:

  • Individually selected probiotics – Combination of bacterial strains with clinical relevance to the patient’s condition
  • Prebiotics – Dietary fibers and nutrients that promote growth of beneficial bacteria
  • Targeted nutritional counseling – Dietary modifications to restore balance and reduce inflammation
  • Leaky gut repair – Gut barrier restoration with supplements like butyrate and L-glutamine
  • Neurotransmitter regulation – Support for serotonin and GABA synthesis through microbiome modulation

📌 Learn how analysis reveals hidden microbiome imbalances

Evidence-Based Approach

Microbiome therapy is grounded in robust scientific research:

  • Clinical trials demonstrate that specific probiotic strains can reduce inflammation, support the gut barrier, and regulate neurotransmitters
  • Studies show improvements in patients with IBS, depression, anxiety, and CFS following microbiome-targeted interventions
  • Patient data are compared with extensive clinical databases to identify the most appropriate probiotic strains

Treatment Process

  1. Stool sample collection – The patient collects a sample at home
  2. Laboratory analysis – The sample is tested for bacterial strains, fungi, viruses, inflammation, and metabolic markers
  3. Data evaluation – Results are cross-referenced with scientific databases to identify imbalances
  4. Personalized plan – An individualized protocol is created, including selected pre- and probiotics and dietary guidance
  5. Follow-up – Treatment progress is monitored, with adjustments based on clinical outcomes and retesting

Benefits of Microbiome Therapy

  • Personalized treatment – Tailored to the individual patient’s microbiome and symptoms
  • Evidence-based – Supported by clinical research and documented efficacy
  • Natural approach – Focused on enhancing the body’s own regulatory systems
  • Holistic perspective – Integrates gut health with mental well-being, immune resilience, and metabolic function

📞 For more information or to book an appointment, please contact Orion Biomedica.