Although the human genome is almost identical across individuals, with 99.9% of DNA shared, it is the remaining 0.1% that shapes each person’s unique genetic profile. These variations, known as polymorphisms, may influence susceptibility to specific diseases. They are not deterministic, but they can indicate predispositions. Understanding these risk factors allows for targeted prevention and personalized treatment strategies.
While we cannot change our genetic code, we can influence how genes are expressed through lifestyle choices and medical interventions—reducing disease risk and promoting long-term health.
DNA: The Body’s Genetic Blueprint
Each cell in the body contains 23 pairs of chromosomes, carrying the genetic instructions that define the body’s structure and function. The genes within our DNA code for proteins that regulate nearly every biological process. Small variations, mutations or polymorphisms, can influence how the body maintains health and responds to environmental factors.
Epigenetics: How the Environment Shapes Gene Expression
Epigenetics examines how genes are activated or silenced without altering the DNA sequence itself. Environmental influences such as nutrition, stress, sleep, physical activity, and exposure to toxins can alter gene expression through mechanisms like DNA methylation and histone modification.
Epigenetic profiles can offer insights into aging, metabolic health, immune function, stress response, and physical performance. This knowledge may be used to personalize lifestyle recommendations and therapeutic interventions.
Available Genetic Profiles
All analyses are performed in collaboration with biovis Diagnostik MVZ GmbH in Limburg-Eschhofen, Germany.
Basic Profile
Evaluates genetic predispositions to common health conditions such as cardiovascular disease, metabolic syndrome, lipid disorders, and inflammation.
Includes 14 gene variants across 12 genes:
- APOC3 – Elevated cholesterol and triglycerides, cardiovascular risk
- APOA5 – Risk for metabolic syndrome
- APOE – E4 variant linked to higher Alzheimer’s risk
- MTHFR – Reduced folate metabolism, elevated homocysteine
- COMT – Stress processing, dopamine metabolism
- CYP1A2 – Affects caffeine metabolism and liver detoxification
Detox Profile
Assesses genetic variants that influence liver detoxification capacity.
Includes 19 variants across 14 genes:
- CYP1A1, CYP1A2, CYP2B6 – Phase I detoxification
- GSTM1, GSTP1, GSTT1 – Phase II detoxification
- MTHFR – Methylation and detox pathways
- SOD2 – Cellular defense against oxidative stress
Relevant in: chronic fatigue, chemical sensitivity, allergies, environmentally linked conditions
Epigenetic Profiles
These panels analyze how lifestyle and environment impact gene expression.
- Healthy Aging – Telomere length, DNA methylation
- Metabolism & Health – Risk for metabolic disorders
- Sport & Exercise – Genetic factors affecting physical performance
- Stress Monitor – Stress load and recovery capacity
Pharmacogenetics
Identifies genetic variations that influence drug metabolism and efficacy.
Key genes: CYP2D6, CYP2C19, VKORC1, CYP2C9, COMT
Applications in: psychiatry, cardiology, oncology, pain management, anticoagulant therapy
Enables more precise medication choices, optimized dosing, and reduced side effects.
Emotional Balance and Mental Health
Explores genetic contributors to mental health vulnerabilities:
- Depression
- Anxiety
- Stress sensitivity
- Addiction susceptibility
Key genes: 5HTR2A, SLC6A4 (5HTT/SERT), BDNF, COMT, MAO-A
Vitamin Genetics
Analyzes genetic influences on vitamin absorption and metabolism:
- Vitamin D – Genes such as VDR and CYP27B1
- Vitamin B12 – FUT2 polymorphisms
- Vitamin A – BCMO1 variants affecting beta-carotene conversion
Deficiencies may contribute to immune issues, neurological problems, and bone loss.
Oxidative and Nitrosative Stress
Assesses genetic markers linked to the body’s defense against cellular damage from free radicals.
Key genes: SOD2, NQO1, PON1
Impairments in these pathways may increase the risk of:
- Cancer
- Diabetes
- Cardiovascular disease
- Neurodegenerative conditions
Inflammation Genetics
Focuses on genes that regulate inflammatory responses and immune balance.
Key markers:
- IL-1A, IL-1B – Pro-inflammatory cytokines
- TNF-α – High activity linked to chronic inflammation
- IL-1RN – Helps regulate inflammatory levels
Useful for: autoimmune conditions, allergies, and chronic inflammation.
Genetic Risk Profiles for Mental Disorders
Screens for inherited predispositions to:
- Depression
- Anxiety
- PTSD
- Substance dependence
Key markers: 5HTT/SERT, TPH2, BDNF, COMT
📞 For more information or to schedule an appointment, please contact Orion Biomedica.