A personalized immune evaluation may include:
- White blood cell differentials and lymphocyte subset analysis
- Immunoglobulin levels (IgA, IgG, IgM, and subclasses)
- Cytokine patterns (e.g., IL-6, TNF-α, IFN-γ)
- Markers of chronic inflammation (CRP, ESR, fibrinogen)
- Natural killer (NK) cell activity and CD57+ cell counts
- Identification of stealth pathogens or latent infections (e.g., EBV, HHV-6, Mycoplasma, Borrelia)
- Intestinal permeability and mucosal immune status
These data inform how the immune system is functioning—whether underactive, overactive, or dysregulated.
Immune Activation and Neuroinflammation
An activated immune system can influence brain function through:
- Cytokine-mediated signaling → affecting mood, cognition, and energy
- Microglial activation → contributing to neuroinflammation and behavioral symptoms
- Blood–brain barrier permeability → increasing neurotoxic vulnerability
- Cross-talk with the HPA axis → impacting stress responses and circadian regulation
📌 Read about immune-brain interactions
Chronic low-grade inflammation is increasingly recognized in disorders such as depression, anxiety, ADHD, autism spectrum disorder, and chronic fatigue.
Immune-Modulating Strategies
Orion Biomedica offers a personalized approach to immune support, guided by clinical presentation and laboratory findings. Interventions may include:
1. Nutritional and Biochemical Support
- Vitamin D → essential for T-regulatory cell function and inflammatory balance
- Zinc, selenium, and vitamin A → support mucosal barriers and antiviral defense
- Omega-3 fatty acids → modulate inflammatory cytokines and promote resolution pathways
- Glutathione precursors (e.g., NAC, glycine) → support detoxification and antioxidant protection
2. Herbal and Natural Immunomodulators
- Echinacea, astragalus, and Andrographis → may support innate immunity
- Curcumin and resveratrol → reduce inflammatory signaling and oxidative stress
- Medicinal mushrooms (e.g., Reishi, Cordyceps) → support NK cell activity and immune coordination
These are selected individually and integrated into broader care strategies, not used generically.
Addressing Hidden Infections
Latent or chronic infections may contribute to persistent immune activation and symptoms. Common targets include:
- Epstein–Barr virus (EBV)
- Human herpesvirus 6 (HHV-6)
- Borrelia burgdorferi (Lyme)
- Bartonella, Babesia, Mycoplasma, Chlamydia pneumoniae
Testing is considered when clinical indicators and immune markers suggest unresolved infection.
📌 Read about post-viral syndromes
Management may involve:
- Antiviral or antimicrobial strategies (conventional or botanical)
- Immune-supportive nutrients and antioxidants
- Inflammation-reducing protocols to restore immune equilibrium
Autoimmune-Related Immune Imbalance
In cases where immune activity targets self-tissues, additional modulation may be necessary:
- Identification of autoantibodies (e.g., ANA, TPO, anti-GAD)
- Gut barrier assessment (zonulin, LPS antibodies)
- Anti-inflammatory dietary protocols (e.g., gluten-free, low lectin, or low histamine diets)
- Support for immune tolerance through micronutrients and targeted probiotics
Long-Term Immune Health
Immune regulation is a dynamic process requiring ongoing evaluation, especially in individuals with:
- Chronic inflammation
- Recurrent infections
- Post-infectious fatigue
- Neuroinflammatory or autoimmune features
Long-term strategies may include rhythm stabilization, sleep optimization, stress management, and environmental reduction of immune triggers.
📞 For more information or to schedule a consultation, please contact Orion Biomedica.